Tuomo Niemelä - the polyporologist - turns sixty

The Sixty - Ninth

IT is a privilege to have been asked to give the sixty-ninth Mary Scott Newbold Lecture. The list of my predecessors is indeed distinguished. The topic, cardiac failure, was chosen because my colleagues and I have been concerned with this problem for almost a quarter of a century. In this lecture I propose to outline my present concepts based on the evolution of thinking which has resulted from...

Crumbs turns the corner

rumbs (Crb) helps flies distinguish apical from basal in their epithelia. Now two new studies show that it is required for cell expansion independently of its specification of apical polarity. During cell expansion, the apical domain of photoreceptors elongates perpendicular to the apical–basal axis so that the domain can extend from the top to the bottom of the fly eye. The process may be cons...

Niemelä and Schwind : Proof Systems for Nonmonotonic Logics

A survey of proof systems for nonmonotonic logics is presented. In particular , proof methods for default logics, nonmonotonic modal logics, circum-scription, and conditional logics are discussed.

Estrogen turns down "the AIRE".

Genetic alterations are known drivers of autoimmune disease; however, there is a much higher incidence of autoimmunity in women, implicating sex-specific factors in disease development. The autoimmune regulator (AIRE) gene contributes to the maintenance of central tolerance, and complete loss of AIRE function results in the development of autoimmune polyendocrinopathy syndrome type 1. In this i...

The General Theory after sixty years